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Leptin signaling and leptin resistance

Yingjiang Zhou, Liangyou Rui

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 207-222 doi: 10.1007/s11684-013-0263-5

Abstract: Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesityThis review is focused on recent advance about leptin action, leptin signaling, and leptin resistance

Keywords： leptin signaling leptin receptor energy balance leptin resistance obesity

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Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3, Pages 222-230 doi: 10.15302/J-FASE-2016106

Abstract: AMPK is the energy status sensor, the core nutrient signaling component and the metabolic kinase of cellsThis review mainly focuses on the mechanism of autophagy regulated by nutrient signaling especially for

Keywords： Autophagy ULK1 complex VPS34 complex AMPK mTOR nutrient signaling

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How to Deal with Revolutions in Train Control Systems

Hideo Nakamura

Engineering 2016, Volume 2, Issue 3, Pages 380-386 doi: 10.1016/J.ENG.2016.03.015

Abstract:

Train control systems ensure the safety of railways. This paper begins with a summary of the typical train control systems in Japan and Europe. Based on this summary, the author then raises the following question regarding current train control systems: What approach should be adopted in order to enhance the functionality, safety, and reliability of train control systems and assist in commercial operations on railways? Next, the author provides a desirable architecture that is likely to assist with the development of new train control systems based on current information and communication technologies. A new unified train control system (UTCS) is proposed that is effective in enhancing the robustness and competitiveness of a train control system. The ultimate architecture of the UTCS will be only composed of essential elements such as point machines and level crossing control devices in the field. Finally, a processing method of the UTCS is discussed.

Keywords： Train control system Railway signaling Communication-based train control system Automatic train protection

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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway

Keywords： apigenin aminoglycosides ototoxicity oxidative stress Nrf2 signaling pathway

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: pathways, including Wnt and Notch signaling.The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleBoth signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochleaIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditory

Keywords： inner ear cochlea hair cell regeneration Wnt Notch signaling pathways

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: the levels of calcium ions (Ca²⁺) and the expression of key genes involved in the calcium signaling

Keywords： melanoma neuropilin and tolloid-like 2 Ca²⁺/CaMKII signaling pathway

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NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 1-7 doi: 10.1007/s11684-009-0018-5

Abstract: Physiologically, ROS are involved in many signaling cascades that contribute to normal processes.As signaling messengers, ROS are able to oxidize many targets such as DNA, proteins and lipids, whichThe present review summarizes recent advances in our comprehensive understanding of ROS-linked signaling

Keywords： free radicals tumor phox cell proliferation cancer therapy

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Function of Slit/Robo signaling in breast cancer

Feng Gu,Yongjie Ma,Jiao Zhang,Fengxia Qin,Li Fu

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 431-436 doi: 10.1007/s11684-015-0416-9

Abstract: The Slit/Robo signaling pathway is reportedly involved in breast cancer development and metastasis.induces its tumor suppressive effects possibly by inactivating the β-catenin/LEF/TCF and PI3K/Akt signalingFurthermore, loss of Slit proteins or their Robo receptors upregulates the CXCL12/CXCR4 signaling axisThis review includes recent studies on the functions of Slit/Robo signaling in breast cancer and its

Keywords： Slit/Robo hypermethylation β-catenin CXCL12/CXCR4 migration

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: -catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and disease-catenin signaling pathway has recently been identified and their exact roles in HCC pursued.

Keywords： interacting complicated understanding embryogenesis activation organism development

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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract: This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs

Keywords： planar cell polarity neural tube defects rare mutations

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ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3, Pages 316-332 doi: 10.15302/J-FASE-2022441

Abstract:

● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.

Keywords： Nitrogen root system architecture phytohormone crosstalk nitrogen-use efficiency breeding strategy

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: mutations, leading to abnormal expression of downstream target genes and aberrant activation of various signalingIn particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular

Keywords： T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1, Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by somereceptor (or cPRL receptor), indicating that SOCS1a and SOCS1b proteins can negatively regulate GH/PRL signaling

Keywords： chicken SOCS1a SOCS1b growth hormone prolactin

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract: In this review, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularlyWe present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellular

Keywords： p21-activated kinase 1 (PAK1) heart

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Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 387-411 doi: 10.1007/s11684-018-0646-8

Abstract: epithelial-mesenchymal transition (EMT) induced by TGF-β, in relation to crosstalk with some other signalingRecent findings also strongly suggested that targeting TGF-β signaling using specific inhibitors

Keywords： TGF-β EMT lung cancer pancreatic cancer latent form immune function GARP